PERDIX (Programmed Eulerian Routing for DNA Designs using X-overs) is a free, open-source resource for the fully autonomous design of arbitrary 2D scaffolded DNA origami nanostructures.
DNA can be programmed to robustly self-assemble into pre-defined nanoscale structures of nearly arbitrary 2D and 3D shape using the principle of scaffolded DNA origami, invented by Dr. Paul Rothemund in 2006. This website offers a free online portal to the PERDIX design software that automatically converts any 2D polygonal mesh file specified using simple Computer-Aided Design (CAD) into the synthetic DNA sequences needed to synthesize the target object. In short, PERDIX offers the ability to “print” your 2D nanometer-scale geometry using DNA.
- For Microsoft Windows without a MATLAB license, download here
- For Microsoft Windows with MATLAB installed, download here
- Requirements: MATLAB, Python 2.7 and Shapely 1.6.4 python package
- For Mac OS X, download here